IONS · Ionis Pharmaceuticals, Inc.
$56.55
-1.18% last session
End-of-day data · updated 2026-07-28
Market cap
$9B
Enterprise value
$10B
Trailing P/E
—
Forward P/E
-52.4
Dividend yield
—
Beta
0.36
Avg volume
3M
Employees
1K
2D change
-1.04%
5D change
0.16%
10D change
2.89%
30D change
-31.07%
60D change
-26.85%
MTD change
-29.33%
YTD change
-29.26%
Analyst Outlook
Analyst estimates change daily — follow the shifts on the Estimate Trends page.
Technical Analysis
Analyst sentiment over time — IONS
Rec Mean (blue, left — higher = more bullish) vs. price targets (right).
Investment Bank Ratings as of 2026-07-21
Latest call per bank · past 12 months
RBC Capital
Outperform$85.00
+50.3% vs priceMorgan Stanley
Overweight$110
+94.5% vs priceBarclays
Overweight$90.00
+59.2% vs priceCitigroup
Buy$100
+76.8% vs priceJefferies
Buy$90.00
+59.2% vs priceGoldman Sachs
Neutral$75.00
+32.6% vs priceBank of America
Buy$111
+96.3% vs priceWells Fargo
Overweight$100
+76.8% vs priceJP Morgan
Overweight$80.00
+41.5% vs priceUBS
Neutral$46.00
-18.7% vs priceRecent rating actions
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-07-21 | Guggenheim | Maintains | Buy | $106 → $89.00 |
| 2026-07-16 | Wolfe Research | Downgrade | Outperform → Peer Perform | $0.00 |
| 2026-07-13 | RBC Capital | Maintains | Outperform | $100 → $85.00 |
| 2026-07-10 | HC Wainwright & Co. | Maintains | Buy | $130 → $125 |
| 2026-07-10 | Morgan Stanley | Maintains | Overweight | $130 → $110 |
| 2026-07-10 | Barclays | Maintains | Overweight | $115 → $90.00 |
| 2026-07-10 | Canaccord Genuity | Maintains | Buy | $110 → $95.00 |
| 2026-07-10 | Citigroup | Maintains | Buy | $115 → $100 |
Ratings and price targets are the published opinions of the issuing banks, compiled from Yahoo Finance rating actions — not investment advice.
Signal Summary as of 2026-07-28
- RSI (14): RSI is 30 — neutral momentum, neither overbought nor oversold.
- Price vs 50-day MA: Trading 22.2% below the 50-day MA ($71.06).
- Price vs 200-day MA: Trading 26.8% below the 200-day MA ($75.49).
- MA cross: The 50-day MA sits below the 200-day MA (death-cross regime) — the longer-term trend points down.
- MACD (12,26,9): MACD histogram is negative (-0.62) — short-term momentum is fading.
- 52-week range: Price sits between the 52-week low ($40.69) and high ($86.50).
IONS Price Chart
Loading chart for IONS…
Fundamentals
About Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 which is in Phase 3 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.
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Data is sourced from end-of-day snapshots and refreshed daily before the US market open — nothing on this page is real-time. Figures can contain vendor errors. This page is for information only and is not investment advice.