SYRE · Spyre Therapeutics, Inc.
$102.13
-0.08% last session
End-of-day data · updated 2026-07-28
Market cap
$9B
Enterprise value
$8B
Trailing P/E
—
Forward P/E
-32.0
Dividend yield
—
Beta
3.02
Avg volume
1M
Employees
0K
2D change
—
5D change
0.05%
10D change
-0.19%
30D change
13.82%
60D change
36.11%
MTD change
12.54%
YTD change
205.37%
Analyst Outlook
Analyst estimates change daily — follow the shifts on the Estimate Trends page.
Technical Analysis
Analyst sentiment over time — SYRE
Rec Mean (blue, left — higher = more bullish) vs. price targets (right).
Investment Bank Ratings as of 2026-07-28
Latest call per bank · past 12 months
Deutsche Bank
Buy$135
+32.2% vs priceCitigroup
Buy$97.00
-5.0% vs priceWells Fargo
Overweight$90.00
-11.9% vs priceJefferies
Buy$85.00
-16.8% vs priceRecent rating actions
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-07-28 | Wolfe Research | Downgrade | Outperform → Peer Perform | $0.00 |
| 2026-07-13 | Mizuho | Maintains | Outperform | $84.00 → $120 |
| 2026-06-23 | Deutsche Bank | Maintains | Buy | $115 → $135 |
| 2026-06-15 | BTIG | Maintains | Buy | $98.00 → $112 |
| 2026-06-04 | Deutsche Bank | Maintains | Buy | $102 → $115 |
| 2026-05-06 | Citigroup | Maintains | Buy | $64.00 → $97.00 |
| 2026-05-06 | Stifel | Maintains | Buy | $92.00 → $107 |
| 2026-04-17 | Jones Trading | Maintains | Buy | $64.00 → $95.00 |
Ratings and price targets are the published opinions of the issuing banks, compiled from Yahoo Finance rating actions — not investment advice.
Signal Summary as of 2026-07-28
- RSI (14): RSI is 57 — neutral momentum, neither overbought nor oversold.
- Price vs 50-day MA: Trading 16.3% above the 50-day MA ($85.94).
- Price vs 200-day MA: Trading 95.3% above the 200-day MA ($51.19).
- MA cross: The 50-day MA sits above the 200-day MA (golden-cross regime) — the longer-term trend points up.
- MACD (12,26,9): MACD histogram is negative (-0.38) — short-term momentum is fading.
- 52-week range: Price is within 5% of the 52-week high ($102.70).
SYRE Price Chart
Loading chart for SYRE…
Fundamentals
About Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4ß7 and anti-TL1A mAbs; SPY130, a combination anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.
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Data is sourced from end-of-day snapshots and refreshed daily before the US market open — nothing on this page is real-time. Figures can contain vendor errors. This page is for information only and is not investment advice.